31 research outputs found
iDataCool: HPC with Hot-Water Cooling and Energy Reuse
iDataCool is an HPC architecture jointly developed by the University of
Regensburg and the IBM Research and Development Lab B\"oblingen. It is based on
IBM's iDataPlex platform, whose air-cooling solution was replaced by a custom
water-cooling solution that allows for cooling water temperatures of 70C/158F.
The system is coupled to an adsorption chiller by InvenSor that operates
efficiently at these temperatures. Thus a significant portion of the energy
spent on HPC can be recovered in the form of chilled water, which can then be
used to cool other parts of the computing center. We describe the architecture
of iDataCool and present benchmarks of the cooling performance and the energy
(reuse) efficiency.Comment: 12 pages, 7 figures, proceedings of ISC 201
Modelling cancer progression using Mutual Hazard Networks
Motivation: Cancer progresses by accumulating genomic events, such as mutations and copy number alterations, whose chronological order is key to understanding the disease but difficult to observe. Instead, cancer progression models use co-occurence patterns in cross-sectional data to infer epistatic interactions between events and thereby uncover their most likely order of occurence. State-of-the-art progression models, however, are limited by mathematical tractability and only allow events to interact in directed acyclic graphs, to promote but not inhibit subsequent events, or to be mutually exclusive in distinct groups that cannot overlap.
Results: Here we propose Mutual Hazard Networks (MHN), a new Machine Learning algorithm to infer cyclic progression models from cross-sectional data. MHN model events by their spontaneous rate of fixation and by multiplicative effects they exert on the rates of successive events. MHN compared favourably to acyclic models in cross-validated model fit on four datasets tested. In application to the glioblastoma dataset from The Cancer Genome Atlas, MHN proposed a novel interaction in line with consecutive biopsies: IDH1 mutations are early events that promote subsequent fixation of TP53 mutations.
Availability Implementation and data are available at https://github.com/RudiSchill/MHN
QPACE 2 and Domain Decomposition on the Intel Xeon Phi
We give an overview of QPACE 2, which is a custom-designed supercomputer
based on Intel Xeon Phi processors, developed in a collaboration of Regensburg
University and Eurotech. We give some general recommendations for how to write
high-performance code for the Xeon Phi and then discuss our implementation of a
domain-decomposition-based solver and present a number of benchmarks.Comment: plenary talk at Lattice 2014, to appear in the conference proceedings
PoS(LATTICE2014), 15 pages, 9 figure
Remnant index theorem and low-lying eigenmodes for twisted mass fermions
We analyze the low-lying spectrum and eigenmodes of lattice Dirac operators
with a twisted mass term. The twist term expels the eigenvalues from a strip in
the complex plane and all eigenmodes obtain a non-vanishing matrix element with
gamma-5. For a twisted Ginsparg-Wilson operator the spectrum is located on two
arcs in the complex plane. Modes due to non-trivial topological charge of the
underlying gauge field have their eigenvalues at the edges of these arcs and
obey a remnant index theorem. For configurations in the confined phase we find
that the twist mainly affects the zero modes, while the bulk of the spectrum is
essentially unchanged.Comment: 10 pages, 4 figures. Two comments added. To appear in Phys. Lett.
BITES: Balanced Individual Treatment Effect for Survival data
Estimating the effects of interventions on patient outcome is one of the key aspects of personalized medicine. Their inference is often challenged by the fact that the training data comprises only the outcome for the administered
treatment, and not for alternative treatments (the so-called counterfactual outcomes). Several methods were suggested for this scenario based on observational data, i.e.~data where the intervention was not applied randomly, for both continuous and binary outcome variables. However, patient outcome is often recorded in terms of time-to-event data, comprising right-censored event
times if an event does not occur within the observation period. Albeit their enormous importance, time-to-event data is rarely used for treatment optimization.
We suggest an approach named BITES (Balanced Individual Treatment Effect for Survival data), which combines a treatment-specific semi-parametric Cox loss with a treatment-balanced deep neural network; i.e.~we regularize differences between treated and non-treated patients using Integral Probability Metrics (IPM). We show in simulation studies that this approach outperforms the state
of the art. Further, we demonstrate in an application to a cohort of breast cancer patients that hormone treatment can be optimized based on six routine parameters. We successfully validated this finding in an independent cohort.
BITES is provided as an easy-to-use python implementation